In the United States, recreational drugs continue to play a prominent role in drug use disorders and fatalities. Included in this category are psychostimulant drugs such as cocaine, which is well-known for its euphoric effects and abuse potential. Cocaine produces euphoria by blocking the reuptake of neurotransmitters, that is, dopamine, norepinephrine, and serotonin. Although cocaine produces effects users find desirable such as increased energy, libido, and heightened alertness, it is also responsible for the negative effects of insomnia, paranoia, irritability, and anxiety when used in larger doses. Even with these negative effects, cocaine use disorder persists due to the continuing stimulation of the brain's reward circuitry, further worsened by the user's increasing tolerance and dependence on the drug. (author introduction) #HES4A